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The giant-cell glioblastoma is a histological variant of glioblastoma, presenting a prevalence of bizarre, multinucleated (more than 20 nuclei) giant (up to 400 μm diameter) cells. It occasionally shows an abundant stromal reticulin network and presents a high frequency of ''TP53'' gene mutations. Symptoms and signs are similar to those of the ordinary glioblastoma. Methodology of diagnosis and treatment are the same. Prognosis is similar to the ordinary glioblastoma (about 12 months). Some authors (see later) refer cases with a slightly better outcome. ==Historical annotation== The giant-cell glioblastoma was originally termed "monstrocellular sarcoma", because of its stromal reticulin network, but the astrocytic nature of the tumor was firmly established through the consistent GFAP expression analysis. 抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Giant-cell glioblastoma」の詳細全文を読む スポンサード リンク
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